Selected publications
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Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation
Benek, O., Vaskova, M., Miskerikova, M., Schmidt, M., Andrys, R., Rotterova, A., Skarka, A., Hatlapatkova, J., Karasova, J. Z., Medvecky, M., Hroch, L., Vinklarova, L., Fisar, Z., Hroudova, J., Handl, J., Capek, J., Rousar, T., Kobrlova, T., Dolezal, R., Soukup, O., & 3 others , 5 Oct 2023, In: European Journal Of Medicinal Chemistry. 258, 18 p., 115593.Research output: Contribution to journal › Article › peer-review
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Open access
Willin/FRMD6 mediates mitochondrial dysfunction relevant to neuronal Aβ toxicity
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 6 Oct 2022, In: Cells. 11, 19, 27 p., 3140.Research output: Contribution to journal › Article › peer-review
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Open access
Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.Research output: Contribution to journal › Review article › peer-review
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Open access
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.Research output: Contribution to journal › Article › peer-review
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Open access
Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
Cheng, Y., Buchan, M., Vitanova, K., Aitken, L., Gunn-Moore, F. J., Ramsay, R. R. & Doherty, G., 13 Oct 2020, In: Journal of Neurochemistry. 155, 2, p. 191-206 e15003.Research output: Contribution to journal › Article › peer-review
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Tacrine – benzothiazoles: novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems
Nepovimova, E., Svobodova, L., Dolezal, R., Hepnarova, V., Junova, L., Jun, D., Korabecny, J., Kucera, T., Gazova, Z., Motykova, K., Kubackova, J., Bednarikova, Z., Janockova, J., Jesus, C., Cortes, L., Pina, J., Rostohar, D., Serpa, C., Soukup, O., Aitken, L., & 10 others , 28 Dec 2020, (E-pub ahead of print) In: Bioorganic Chemistry. In-Press, 104596.Research output: Contribution to journal › Article › peer-review
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Open access
Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment
Aitken, L., Benek, O., McKelvie, B., Hughes, R. E., Hroch, L., Schmidt, M., Major, L. L., Vinklarova, L., Kuca, K., Smith, T. K., Musilek, K. & Gunn-Moore, F. J., 29 Jul 2019, In: Molecules. 24, 15, 2757.Research output: Contribution to journal › Article › peer-review
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Open access
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
Benek, O., Hroch, L., Aitken, L., Gunn-Moore, F., Vinklarova, L., Kuca, K., Perez, D. I., Perez, C., Martinez, A., Fisar, Z. & Musilek, K., 2018, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 33, 1, p. 665-670 6 p.Research output: Contribution to journal › Article › peer-review
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Open access
6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: design, synthesis and in vitro evaluation
Benek, O., Hroch, L., Aitken, L., Dolezal, R., Guest, P., Benkova, M., Soukup, O., Musil, K., Hughes, R., Kuca, K., Smith, T. K., Gunn-Moore, F. & Musilek, K., Jun 2017, In: Medicinal Chemistry. 13, 4, p. 345-358 14 p.Research output: Contribution to journal › Article › peer-review
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Open access
In vitro assay development and HTS of small molecule human ABAD/17β-HSD10 inhibitors as therapeutics in Alzheimer’s Disease
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Jones, P. S., Smith, T. K., McElroy, S. P. & Gunn-Moore, F. J., Jul 2017, In: SLAS Discovery. 22, 6, p. 676-685 11 p.Research output: Contribution to journal › Article › peer-review